Differential diagnosis for the salivary gland mass includes primary soft tissue neoplasia (fibrosarcoma) with invasion of the parotid salivary gland or – even though rare in canine – primary neoplasia of the parotid salivary gland (such as adenocarcinoma or less likely adenoma).For further workup – if not performed yet – FNA samples or biopsy are essential. Surgical excision is advised. The right thyroid gland presents a mass lesion compatible with primary neoplasia. Possible differential diagnosis are cystic adenocarcinoma or less likely adenoma. In dogs these are rarely functional. Surgical removal of the right thyroid is the therapy of choice. FNA samples from the right superficial cervical lymph node are essential prior to surgery for complete staging. The findings of the right adrenal gland are consistent with primary neoplasia. Possible differentials include functional/non-functional adenoma or adenocarcinoma, pheochromocytoma. Invasion of the phrenicoabdominal vein is likely, invasion of the caudal vena cava cannot be ruled out. The potential of vascular invasion increases the odds of a primary malignancy.