Case Study

Protein losing nephropathy, glomerulonephritis, and uremic gastritis in a 3 year old MI Labrador Retriever

A 3-year-old male Labrador Retriever dog was presented for anorexia and weight loss. CBC was within normal limits, however blood chemistry showed hyperproteinemia, hypoalbuminemia, low albumin/globulin ratio, marked azotemia, hyperphosphatemia, mild hypocalcemia, hyperkalemia, and hyperamylasemia. T4 was within normal range. The urine had a cloudy appearance; 3+ proteinuria and 3+ hematuria were present on urinalysis.

Sonographic Differential Diagnosis

Glomerulonephritis – protein losing nephropathy. Suspect Lyme nephritis, or similar immune complex disease. Uremic gastritis.

Image Interpretation

The kidneys present thickened and uniformly echogenic cortices that are hypervascular on power Doppler evaluation. Slight pyelectasia is present due either to fluid therapy (< 0.3 cm) or due to infection (pyelonephritis). The gastric wall is edematous and uniformly thickened consistent with gastritis.

DX

Protein-losing nephropathy, glomerulonephritis, uremic gastritis

Outcome

The patient was euthanized due to financial concerns and poor prognosis.

Clinical Differential Diagnosis

Renal disease – acute, chronic, congenital, pyelonephritis, neoplasia. Nephrotic syndrome. Primary glomerulonephritis with secondary renal failure

Sampling

None

Video

Patient Information

Patient Name : Jessie M

Gender : Male, Intact

Species : Canine

Type of Imaging : Ultrasound

Status : Complete

Liz Wuz Here : Yes

Code : 06_00022

Clinical Signs

Anorexia
Weight loss

Images

Blood Chemistry

Albumin, Low
Albumin/Globulin Ratio, Low
Amylase, High
Azotemia
BUN high
Calcium, High
Calcium, Low
Creatinine, High
Phosphorus, High
Potassium, High
Total Protein, High

Clinical Signs

Anorexia
Weight loss

Urinalysi

Appearance Turbid
Blood Present
Protein Present