A 1-year-old NM German shepherd with a history of PU/PD and hypercalcemia was presented for evaluation of lethargy, weight loss, and anorexia. Left-sided nephromegaly was present on survey radiographs. Abnormalities on serum biochemistry were hypercalcemia, azotemia, and mildly elevated ALT activity.
Multicentric lymphadenopathy involving cranial mediastinum and mid caudal abdomen.
Medullary rim kidney, potentially owing to hypercalcemia or emerging neoplasia within the kidney.
FNA of the lymph node masses and cranial mediastinal mass is recommended. Hypercalcemia is likely owing to malignancy. Lymphoma or similar neoplasia is suspected.
The chest in this patient presented a cranial mediastinal mass. This was comprised of multiple lymph nodes. A mid-abdominal lymph node mass was noted and measured 4 x 3 cm. There are separate, mixed hypoechoic mid-abdominal lymph node masses. The kidneys were swollen in this patient. The left kidney measured 7.4 cm with medullary rim sign and loss of corticomedullary detail. The right kidney revealed similar changes to the left kidney. The right kidney measured 7.3 cm. Pyelectasia of both kidney was noted.
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Hypercalcemia of malignancy – lymphoma, carcinoma
Fungal disease
Kidney disease secondary to the hypercalcemia
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