Liver: The five slides varied in cellularity. The two most cellular slides had moderate to high numbers of nucleated cells with small amounts of blood. Hepatocytes were present in low to moderate numbers, arranged in cohesive clusters, sometimes entrapped within clot-like aggregates. They often had small amounts of blue-green lipofuscin pigment. There were also moderate numbers of round to cuboidal cells arranged in cohesive clusters, sometimes closely associated with hepatoyte clusters. The cells had round nuclei and small amount of lightly basophilic cytoplasm. Nuclei had coarse chromatin patterns with 2-4 prominent nucleoli that varied in shape and size. There was mild to moderate anisocytosis and mild ankisokaryosis among these cells. Clots containing hepatocytes often exhibited increased proportions of neutrophils and numbers may have been mildly overrepresented in other areas of the slides. Macrophages were present in low to moderate numbers and were typically highly vacuolated and often contained hemosiderin. Pancreas: One slide had small amount of blood with low numbers of nucleated cells. The other two slides had moderate numbers of nucleated cells with little blood and small to moderate amounts of a slightly fibrinous pale eosinophilic material. There were low to moderate numbers of epithelial cells arranted in cohesive clusters and similar in appearance to the atypical cells described above. Some clusters of these cells exhibited mild to moderate cytoplasmic vacuolation. Anisokaryosis was moderate within this population. No pancreatic epithelial cells containing zymogen granules were found. Remaining nucleatecells consisted of low numbers of blood leucotyes and occasional macrophages. Small to moderate amounts of granular basophilic material suggestive of deteriorated cells were also noted. Interpretation: liver: carcinoma (suspected metastatic). Pancreas: carcinoma. Comments: Given the appearance of the slides as well as the sonographic description, the pancreas is likely the site of primary neoplasia, with metastases to the liver. The neoplastic cells appear epithelial but do not contain zymogen granules typical of normal pancreatic cells. This could be because the cells are sufficiently anaplastic as to have lost this feature, but other sources should be considered as well. Histopathology would be required for confirmation.