03_00230 Daffodil N Post hepatic obstruction

Case Study

03_00230 Daffodil N Post hepatic obstruction

A 10-year-old, SF DSH cat was presented for acute onset vomiting and dehydration. Abnormalities on physical examination were icterus and dehydration. Pyuria with low urine SG was present on urinalysis. Urine culture was negative for bacterial growth after 24hrs. CBC and serum biochemistry showed marked leukocytosis with left shift and azotemia. Diffuse intestinal ileus was evident on survey radiographs.

A 10-year-old, SF DSH cat was presented for acute onset vomiting and dehydration. Abnormalities on physical examination were icterus and dehydration. Pyuria with low urine SG was present on urinalysis. Urine culture was negative for bacterial growth after 24hrs. CBC and serum biochemistry showed marked leukocytosis with left shift and azotemia. Diffuse intestinal ileus was evident on survey radiographs.

Sonographic Differential Diagnosis

Post hepatic obstruction with cholangiohepatitis presentation is strongly suggestive for biliary adenocarcinoma at the duodenal papilla, possible bile plug or inflammatory polyp. Heterogenous hepatic changes. Exploratory surgery is recommended with expectations towards inspection of the liver for metastatic lesions, cholecystectomy, and bile duct deviation.

Image Interpretation

The liver in this patient presented a significantly dilated gallbladder with echogenic, suspended, largely immobile debris and thickened gallbladder wall. The gallbladder measured 3.9 x 3.0 cm. Cystic duct and common bile duct were dilated. Lobar ducts were also dilated indicating an obstruction for at least 4 days. The liver itself was coarse with increased portal markings. The common bile duct prior to the duodenal papilla measured 0.8 cm in width with echogenic inflammatory pattern around the common bile duct. Heterogenous, hyperechoic hepatic changes were present and may represent metastatic disease such as that of adenocarcinoma. However, in my experience biliary adenocarcinoma, which is primarily suspected in this case, can present isoechoic, metastatic lesions. Exploratory surgery with expectations towards direct examination of the liver for metastatic lesions as well as bile duct deviation and gallbladder removal. At that time a liver biopsy would also be indicated. The deep right liver lobe presented heterogenous, hyperechoic lesion. This is suggestive for metastatic disease.

DX

Post hepatic obstruction strongly suggestive for biliary adenocarcinoma at the duodenal papilla

Outcome

The patient was treated medically for a few weeks. The patient was not doing well and was euthanized.

Clinical Differential Diagnosis

Liver: cholangio-hepatitis complex, hepatic lipidosis, bacterial/fungal hepatitis, abscess, granuloma, neoplasia, trauma FIP Gallbladder: obstruction (intestinal/pancreatic disease, lith), neoplasia, cholecystitis, rupture

Sampling

None

Patient Information

Gender : Female, Spayed
Species : Feline
Type of Imaging : Ultrasound
Status : Complete

Clinical Signs

  • Dehydration
  • Vomiting

Exam Finding

  • Dehydration
  • Icterus

Images

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Blood Chemistry

  • Azotemia

CBC

  • Left Shift
  • WBC, High

Clinical Signs

  • Dehydration
  • Vomiting

Urinalysi

  • Culture negative
  • Specific Gravity Low
  • WBCs Present
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