03-00404 Nephthys M Suspect multicentric LSA——–NEED DX, SL———

Case Study

03-00404 Nephthys M Suspect multicentric LSA——–NEED DX, SL———

A 13-year-old SF DSH was presented for evaluation of 5-6 days of anorexia and weight loss. Abnormalities on physical examination were dehydration and dilated pupils. Urinalysis showed bilirubinuria. Abnormalities on serum biochemistry were elevated ALP activity and bilirubin.

A 13-year-old SF DSH was presented for evaluation of 5-6 days of anorexia and weight loss. Abnormalities on physical examination were dehydration and dilated pupils. Urinalysis showed bilirubinuria. Abnormalities on serum biochemistry were elevated ALP activity and bilirubin.

Sonographic Differential Diagnosis

Infiltrative liver pattern. This is suggestive for lymphoma or similar neoplasia. Jejunal lymphadenopathy. FNA were performed without complication. Concurrent pleural effusion. This is likely indicative of metastatic disease through the thoracic duct especially if no evidence of cardiac disease is noted. Guarded prognosis.

Image Interpretation

The liver was diffusely hypoechoic and irregular in contour. Hepatic lymph node enlargement was noted at 0.95 cm. The gallbladder was unremarkable. The spleen was largely uniform with mildly swollen and scalloping contour. This is most consistent with reactive hypersplenism with the potential for emerging neoplasia such as lymphoma or mast cell disease. No overt masses were noted. The spleen measured 1.0 cm. The gastrointestinal presentation revealed mild uniform prominence of the gastric mucosa as well as areas of “ropey” small intestinal wall. The intestinal mucosa was slightly irregular, thickened and hyperechoic suggestive of low grade, chronic inflammation. No evidence of obstruction was present. Chronic inflammatory bowel disease is probable with a low possibility of an early neoplastic event such as lymphoma. Full thickness tissue biopsies via open laparotomy would be necessary to rule out this possibility. Jejunal lymph nodes were significantly enlarged, irregular and hypoechoic with pericapsular inflammatory pattern measuring 1.7 x 2.0 cm. Epigastric lymph nodes were also enlarged. The transdiaphragmatic view revealed a mild amount of pleural effusion.

Outcome

None

Clinical Differential Diagnosis

Hemolysis – toxins, hemoplasmosis, immune-mediated hemolytic anemia, neoplasiaLiver – acute hepatitis (viral, bacterial, fungal, toxins), cholangio-hepatitis complex, neoplasia, granulomatous disease, abscessation

Gall bladder – cholecystitis, neoplasia, obstruction

Pancreas – pancreatitis, neoplasia

Patient Information

Gender : Female, Spayed
Species : Feline
Type of Imaging : Ultrasound

Clinical Signs

  • Anorexia
  • Weight loss

Exam Finding

  • Dehydration

Images

maurer_nephthys_liver_lsa_gbmaurer_nephthys_heaptic_ln_lsa_fnamaurer_nephthys_ln_lsa_fna2

Blood Chemistry

  • Alkaline Phosphatase (SAP), High
  • Total Bilirubin, High

Clinical Signs

  • Anorexia
  • Weight loss

Urinalysi

  • Bilirubin Present
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