Lymphoma, Liver and Spleen

Case Of the Month

Lymphoma, Liver and Spleen

A 12-year-old MN Golden Retriever dog with history of arthritis currently on Previcox and Glucosamine, was presented for dyspnea. On physical examination the patient was laterally recumbent and the abdomen was tense on palpation. Radiographs showed a possible foreign body in the stomach.

A 12-year-old MN Golden Retriever dog with history of arthritis currently on Previcox and Glucosamine, was presented for dyspnea. On physical examination the patient was laterally recumbent and the abdomen was tense on palpation. Radiographs showed a possible foreign body in the stomach.

DX

FNAs of both the spleen and liver were consistent with lymphoma.

Outcome

The patient was treated with Benadryl, Dexamethasone SP, and Prednisone. The Madison Wisconsin protocol was recommended. The patient received one dose of Vincristine and was discharged with metronidazole and Pepcid but died at home 24 hours later.

Clinical Differential Diagnosis

GIT – torsion, obstruction (foreign body/neoplasia), intestinal perforation Peritonitis Liver – hepatitis, neoplasia

Sampling

US-guided FNA`s of both the liver and spleen revealed lymphoma.

Sonographic Differential Diagnosis

Aggressive infiltrative splenic and hepatic pattern. This is consistent with lymphoma or round cell neoplasia.

Image Interpretation

The liver and spleen in this patient presented diffuse, micronodular “honeycomb” type appearance with microcystic changes and multiple, small, enlarged target lesions. Fine-needle aspirates were performed. Periportal lymphadenopathy was also noted.

Patient Information

Status : Complete

Images

fnanodules03_00212_fnanodules_0001_0712201112402303_00212_SpleenFNA_0001_07122011124041SpleenFNA
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