Hyperbilirubinemia and small liver

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Hyperbilirubinemia and small liver

  • 2 year old mn Miniature Schnauze in good physical condition presented for anorexia, vomiting, lethargy of 3-4 days duration.
  • Chemistry profile shows increased T.Bil=18.2mg/dl, ALT=260 U/L, and GGT=9 U/L.  Normal chemistries include BUN=11, ALB=3.5 and ALKP=131.  CBC is wnl.  Chemistries done 1 year ago were all normal…BUN was 25.
    • 2 year old mn Miniature Schnauze in good physical condition presented for anorexia, vomiting, lethargy of 3-4 days duration.
    • Chemistry profile shows increased T.Bil=18.2mg/dl, ALT=260 U/L, and GGT=9 U/L.  Normal chemistries include BUN=11, ALB=3.5 and ALKP=131.  CBC is wnl.  Chemistries done 1 year ago were all normal…BUN was 25.
    • Abdominal US shows a small liver and some echogenic fat just caudal to the stomach.  The pancreas itself appeared normal. The gallbladder and CBD also appeared normal with no evidence of mucocele, inflammation, or obstruction.  There were no visible bladder or renal stones.
    • I found a vein branching dorsally off of the PV but could not connect it to the CVC.  The dog did not tolerate pressure to the right abdomen and will likely require sedation for a shunt hunt.
    • The dog improved greatly just on IV fluids.  Recheck lab values are pending. Bile acids were elevated…will post as soon as I get them.
    • Would you pursue a shunt hunt on this dog or is this more likely some kind of cholangiohepatitis/toxin?

Comments

EL

there is echogenic fat ion

there is echogenic fat ion region of right pancreas so pancreatitis likley. The PV banches fine in th evideo and has solid volume so no EHPSS. PV hypoplasia possible  but with the clinical signs/profile I would consider Lepto or bacterial toxin as Lepto will spike BA into shunt levels as well.

EL

there is echogenic fat ion

there is echogenic fat ion region of right pancreas so pancreatitis likley. The PV banches fine in th evideo and has solid volume so no EHPSS. PV hypoplasia possible  but with the clinical signs/profile I would consider Lepto or bacterial toxin as Lepto will spike BA into shunt levels as well.

Electrocute

Ok, thanks!

Ok, thanks!

Electrocute

Ok, thanks!

Ok, thanks!

Electrocute

Bile acid test

Bile acid test results:

Pre=2.3 micromol/L (N=0.0-6.9)

Post=30.3 micromol/L (N=0-14.9)

Electrocute

Bile acid test

Bile acid test results:

Pre=2.3 micromol/L (N=0.0-6.9)

Post=30.3 micromol/L (N=0-14.9)

EL

 
 
This is typical of acute

 
 

This is typical of acute liver insult and/or portal hypoplasia. Macroscopic shunt parameters are usually post > 70… with rare exception. Nice post

See our study on this:

ECVIM 2009 abstract number 2

http://sonopath.com/resources/research-publications

also go to the basic search and use key word shunt from computer or the sonopath ap to see all the shunts you can imagine from the clinical and sonographic perspective:

http://sonopath.com/resources/research-publications

 
EL

 
 
This is typical of acute

 
 

This is typical of acute liver insult and/or portal hypoplasia. Macroscopic shunt parameters are usually post > 70… with rare exception. Nice post

See our study on this:

ECVIM 2009 abstract number 2

http://sonopath.com/resources/research-publications

also go to the basic search and use key word shunt from computer or the sonopath ap to see all the shunts you can imagine from the clinical and sonographic perspective:

http://sonopath.com/resources/research-publications

 
Electrocute

Great, thanks!

Great, thanks!

Electrocute

Great, thanks!

Great, thanks!

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