Hello

We recently heard of a study that was being conducted on subclinical dogs with MVD and the benifits of pimobendan. An associate mentioned that a cardiologist referenced it to them but I have not been able to find the study.

Has it been published?

Is there a downside to starting pimobendan in non-clinical patients?

Thanks. Brent

Hello

We recently heard of a study that was being conducted on subclinical dogs with MVD and the benifits of pimobendan. An associate mentioned that a cardiologist referenced it to them but I have not been able to find the study.

Has it been published?

Is there a downside to starting pimobendan in non-clinical patients?

Thanks. Brent

## Comments

Hi Brent – that is the EPICHi Brent – that is the EPIC study and it is now available in the Journal Of Veterinary Medicine which is open access.

Hi Brent – that is the EPICHi Brent – that is the EPIC study and it is now available in the Journal Of Veterinary Medicine which is open access.

Thanks you I will go read itThanks you I will go read it now! Hopefully has a great ending!

Hi!

It’s basically very

Hi!

It’s basically very simple to explain:

Dogs with DMVD and without congestive heart disease should be treated wth Pimo if:

The mean median time to the primary endpoint was 15 months longer in the Pimo group

Consequence:

Regards!

Peter

Peter

Good reason to do moreGood reason to do more echocardiograms!

Fantastic information! I amFantastic information! I am guessing that they have to meet all the criteria to start pimobendan? Or is there some parameters that are more important?

What is the draw back starting pimobendan if these criteria are not present?

Thanks Brent

Thanks for the summary peterThanks for the summary peter !

Hi!

You’re welcome – this

Hi!

You’re welcome – this is what I’m here for 🙂

@tosullivan:

From the GP’s standpoint, as long as a small breed (<15 kg) patient with known DMVD has a VHS of 10.5 or smaller, Pimobendan is not an option.

From the sonographer’s standpoint: Yes, all criteria should be fulfilled.

Even though this is not scientifically correct, I would personally extrapolate the data to large breed dogs as well, even though the LV-Cornell-Index cut-off of 1.7 could be too low in large breeds. Means, if I have a large breed dog with DMVD and left sided volume overload, I would likely start with Pimo.

Best regards!

Peter

Thanks again!Thanks again!

Peter,Can you show us how to

Peter,

Can you show us how to calculate the left ventricular end-diastolic cornell index?

Thanks

I believe I have found outI believe I have found out how to calculate.

Please confirm:

LVDd (cm)/ Weight kg raised to 0.29

Use a calculator to calculate.

HiIts LVd (cm)/(KM raised to

Hi

Its LVd (cm)/(KM raised to 0.294)

(I mentioned this on my first posting)

sorry for the delay!

Peter

KM is BM 🙂KM is BM 🙂