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Pimobendan in subclinical dogs with MVD

Hello

We recently heard of a study that was being conducted on subclinical dogs with MVD and the benifits of pimobendan. An associate mentioned that a cardiologist referenced it to them but I have not been able to find the study.

Has it been published?

Is there a downside to starting pimobendan in non-clinical patients?

Thanks. Brent

Hello

We recently heard of a study that was being conducted on subclinical dogs with MVD and the benifits of pimobendan. An associate mentioned that a cardiologist referenced it to them but I have not been able to find the study.

Has it been published?

Is there a downside to starting pimobendan in non-clinical patients?

Thanks. Brent

tosullivan

13 responses to “Pimobendan in subclinical dogs with MVD”

  1. Hi Brent – that is the EPIC

    Hi Brent – that is the EPIC study and it is now available in the Journal Of Veterinary Medicine which is open access.

  2. Hi Brent – that is the EPIC

    Hi Brent – that is the EPIC study and it is now available in the Journal Of Veterinary Medicine which is open access.

  4. Hi!
     
    It’s basically very

    Hi!

     

    It’s basically very simple to explain:

    Dogs with DMVD and without congestive heart disease should be treated wth Pimo if:

    • they are small breed (up to 15 kg)
    • they have a systolic heart murmur 3/6 or louder
    • if the VHS is > 10.5
    • If the LA:Ao ratio is 1.6 or larger
    • If the left ventricular end-diastolic cornell index (diameter in cm divided by (BM raised by 0.294)) is 1.7 or larger

     

    The mean median time to the primary endpoint was 15 months longer in the Pimo group

    Consequence:

    • Asymptomatic DMVD needs clinical exam, radiographs, and an ultrasound for decision making
    • You will have to calculate the Cornell Index

    Regards!

     

    Peter

     

    Peter

     

  5. Fantastic information! I am

    Fantastic information! I am guessing that they have to meet all the criteria to start pimobendan? Or is there some parameters that are more important?

    What is the draw back starting pimobendan if these criteria are not present?

    Thanks   Brent

  7. Hi!
     
    You’re welcome – this

    Hi!

     

    You’re welcome – this is what I’m here for 🙂

    @tosullivan:

    From the GP’s standpoint, as long as a small breed (<15 kg) patient with known DMVD has a VHS of 10.5 or smaller, Pimobendan is not an option.

    From the sonographer’s standpoint: Yes, all criteria should be fulfilled.

    Even though this is not scientifically correct, I would personally extrapolate the data to large breed dogs as well, even though the LV-Cornell-Index cut-off of 1.7 could be too low in large breeds. Means, if I have a large breed dog with DMVD and left sided volume overload, I would likely start with Pimo.

    Best regards!

     

    Peter

  9. Peter,
    Can you show us how to

    Peter,

    Can you show us how to calculate the left ventricular end-diastolic cornell index?

    Thanks

     

  10. I believe I have found out

    I believe I have found out how to calculate.

    Please confirm:

    LVDd (cm)/ Weight kg raised to 0.29

    Use a calculator to calculate.

  11. Hi
    Its LVd (cm)/(KM raised to

    Hi

    Its LVd (cm)/(KM raised to 0.294)

    (I mentioned this on my first posting)

    sorry for the delay!

     

    Peter

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