03_00534 Princess C Glycogen hepatocellular vacuolar change

Case Study

03_00534 Princess C Glycogen hepatocellular vacuolar change

A 3-year-old SF Chihuahua mix was presented for evaluation of weight loss and elevated ALT activity (382-390).

 

Sonographic Differential Diagnosis

Structurally unremarkable inflammatory hepatopathy.
There was no structural evidence of disease.
I recommend treatment based on cytology. If lymphoplasmacytic predominance is noted in the inflammatory pattern then antigen surveillance protocol would be recommended. There was no structural evidence of disease that would be responsible for the weight loss.

Image Interpretation

The liver images from right and left intercostal as well as subcostal views revealed subjectively normal liver size, contour, and structure. Parenchymal echogenicity was naturally coarse and hypoechoic to the spleen. Vascular and biliary tracts were of normal volume and no evidence of congestion was noted. The portal vein to vena cava ratio was 1:1 each measuring 0.5 cm. The gallbladder presented thin walls with normal, primarily anechoic content. The cystic and common bile ducts were normal. No pathological hepatic lymphadenopathy was evident. No overt structural evidence of inflammatory, infiltrative or regenerative pathology was noted. Ultrasound-guided FNA of the liver was performed without complication.

DX

FNA, liver: mild to moderate glycogen-type hepatocellular vacuolar change. Possible mild small lymphocytosis.

Outcome

None

Clinical Differential Diagnosis

Vacuolar hepatopathy, reactive hepatopathy, acute hepatitis (viral, bacterial, toxins), drug-induced, infiltrative neoplasia (lymphoma, mast cell tumor)

Sampling

FNA of the liver revealed mild to moderate glycogen-type hepatocellular vacuolar change. Possible mild small lymphocytosis.

Patient Information

Gender : Female, Spayed
Species : Canine
Type of Imaging : Ultrasound
Status : Complete

Clinical Signs

  • Weight loss

Images

princess_carvalho_as_liver

Blood Chemistry

  • ALT (SGPT), High

Clinical Signs

  • Weight loss
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