A 3-year-old FS Labrador Retriever dog with history of recent OHE, presented for seizure. Physical exam found patient emaciated, jaundiced, and with decreased skin turgor. In-house chemistry revealed markedly elevated Alkaline Phosphatase, ALT was unable to be determined, hypoamylasemia, low BUN, hyperbilirubinemia, and sample was icteric. CBC found high HCT, high RBC, and low MCHC. ALT analysis was sent out and showed marked elevation. Leptospirosis titer results were negative. Preprandial and postprandial bile acid profile results were both significantly elevated.
A 3-year-old FS Labrador Retriever dog with history of recent OHE, presented for seizure. Physical exam found patient emaciated, jaundiced, and with decreased skin turgor. In-house chemistry revealed markedly elevated Alkaline Phosphatase, ALT was unable to be determined, hypoamylasemia, low BUN, hyperbilirubinemia, and sample was icteric. CBC found high HCT, high RBC, and low MCHC. ALT analysis was sent out and showed marked elevation. Leptospirosis titer results were negative. Preprandial and postprandial bile acid profile results were both significantly elevated. Patient was admitted for I.V. fluid therapy and supportive care. Abdominal radiograph showed decreased detail and small spleen. Coagulation panel run awaiting ultrasound, found prolonged clotting time for PT. Patient continued on fluids, antidiarrheal medication, Lactulose, Vitamin K injections, and antibiotics. Physical exam the following day found patient BAR and extremely icteric.
