I am doing some research and having a hard time finding any references on the possible association of feline pancreatitis and nephritis. A Google and ACVR search has come up pretty unrewarding. It may be that there is no such proven association. Does anyone have any ideas on this?
Has anyone seen this?
Thanks!
I am doing some research and having a hard time finding any references on the possible association of feline pancreatitis and nephritis. A Google and ACVR search has come up pretty unrewarding. It may be that there is no such proven association. Does anyone have any ideas on this?
Has anyone seen this?
Thanks!
Comments
The only veterinary reference
The only veterinary reference that I can dig up is at the end of this comment. In people nephritis is associated with auto-immune pancreatitis, which may occur in the dog (reference below) but not in the cat. Thus, to date there seems to be no proven association between the two conditions in the cat.
J Am Vet Med Assoc. 1996 Sep 15;209(6):1114-6.
Relationship between inflammatory hepatic disease and inflammatory bowel disease, pancreatitis, and nephritis in cats.
Weiss DJ, Gagne JM, Armstrong PJ.
OBJECTIVE:
To determine whether cats with inflammatory hepatic disease had concurrent inflammatory bowel disease (IBD), pancreatitis, or chronic interstitial nephritis.
DESIGN:
Prospective case series.
SAMPLE POPULATION:
78 tissue sections of liver, intestine, pancreas, and kidney from cats that had previous necropsy examinations at the teaching hospital.
PROCEDURE:
We reviewed histologic sections of liver, intestine, pancreas, and kidney from cats that had previous necropsy examinations and determined the prevalence of lymphocytic portal hepatitis, cholangiohepatitis, IBD, pancreatitis, and chronic interstitial nephritis, and the relationship among them.
RESULTS:
36 cats had lymphocytic portal hepatitis, 18 had cholangiohepatitis, and 24 did not have inflammatory hepatic disease. The prevalence of IBD (10/36; 28%) and pancreatitis (5/36; 14%) in cats with lymphocytic portal hepatitis was not significantly different from cats without inflammatory hepatic disease. The prevalence of IBD (15/18; 83%) and pancreatitis (9/18; 50%) was greater (P < 0.05) for cats with cholangiohepatitis, compared with cats without inflammatory hepatic disease. Thirty-nine percent of cats (7/18) with cholangiohepatitis had IBD and pancreatitis. Evidence of IBD in association with cholangiohepatitis was characterized by infiltration of lymphocytes and plasma cells into the lamina propria; however, neutrophilic infiltrates also were found in 6 of 15 (40%) cats with cholangiohepatitis. Pancreatitis was mild in all cats. CLINICAL IMPLICATIONS: Cats with a diagnosis of cholangiohepatitis should be evaluated for IBD and pancreatitis. J Vet Intern Med. 2011 Jul-Aug;25(4):797-804. Characterization of chronic pancreatitis in English Cocker Spaniels. Watson PJ, Roulois A, Scase T, Holloway A, Herrtage ME. BACKGROUND: Chronic pancreatitis (CP) is common in dogs. The cause is unknown. In humans, different causes of pancreatitis have histologically distinct appearances. The histopathologic lesions in English Cocker Spaniels (ECS) with CP were noted to be histologically different than those of other breeds with CP. HYPOTHESIS: CP in ECS is distinct from CP in other breeds and is characterized by a duct destruction similar to what is observed in autoimmune CP of humans. ANIMALS: Eight ECS and 9 other breeds with histologically confirmed CP recruited over an 8-year period and 50 postmortem control dogs with CP. METHODS: Clinical, clinicopathological, and ultrasonographic findings were recorded. Histological sections were compared with a normal dog and 59 dogs of other breeds with CP. Immunohistochemistry using anti-CD3, anti-CD79a, and anti-cytokeratin antibodies was used to evaluate distribution and type of lymphocytic inflammation and appearance of pancreatic ducts. RESULTS: Four male and 4 female ECS presented at a mean age of 7.2 years. Clinical signs were similar in ECS and other breeds. The pancreas was enlarged and hypoechoic in 4 ECS and 2 controls. Histopathology was characterized by interlobular and periductular fibrosis and inflammation in ECS compared with intralobular disease in most other breeds. Immunohistochemistry identified prominent anti-CD3(+) lymphocytic infiltrates around venules and ducts and a marked absence of interlobular ducts in ECS compared with mixed T-cell infiltration and ductular hyperplasia in most other breeds with CP. CONCLUSIONS AND CLINICAL IMPORTANCE: CP in ECS is distinct from CP in other breeds and is notably duct destructive.
The only veterinary reference
The only veterinary reference that I can dig up is at the end of this comment. In people nephritis is associated with auto-immune pancreatitis, which may occur in the dog (reference below) but not in the cat. Thus, to date there seems to be no proven association between the two conditions in the cat.
J Am Vet Med Assoc. 1996 Sep 15;209(6):1114-6.
Relationship between inflammatory hepatic disease and inflammatory bowel disease, pancreatitis, and nephritis in cats.
Weiss DJ, Gagne JM, Armstrong PJ.
OBJECTIVE:
To determine whether cats with inflammatory hepatic disease had concurrent inflammatory bowel disease (IBD), pancreatitis, or chronic interstitial nephritis.
DESIGN:
Prospective case series.
SAMPLE POPULATION:
78 tissue sections of liver, intestine, pancreas, and kidney from cats that had previous necropsy examinations at the teaching hospital.
PROCEDURE:
We reviewed histologic sections of liver, intestine, pancreas, and kidney from cats that had previous necropsy examinations and determined the prevalence of lymphocytic portal hepatitis, cholangiohepatitis, IBD, pancreatitis, and chronic interstitial nephritis, and the relationship among them.
RESULTS:
36 cats had lymphocytic portal hepatitis, 18 had cholangiohepatitis, and 24 did not have inflammatory hepatic disease. The prevalence of IBD (10/36; 28%) and pancreatitis (5/36; 14%) in cats with lymphocytic portal hepatitis was not significantly different from cats without inflammatory hepatic disease. The prevalence of IBD (15/18; 83%) and pancreatitis (9/18; 50%) was greater (P < 0.05) for cats with cholangiohepatitis, compared with cats without inflammatory hepatic disease. Thirty-nine percent of cats (7/18) with cholangiohepatitis had IBD and pancreatitis. Evidence of IBD in association with cholangiohepatitis was characterized by infiltration of lymphocytes and plasma cells into the lamina propria; however, neutrophilic infiltrates also were found in 6 of 15 (40%) cats with cholangiohepatitis. Pancreatitis was mild in all cats. CLINICAL IMPLICATIONS: Cats with a diagnosis of cholangiohepatitis should be evaluated for IBD and pancreatitis. J Vet Intern Med. 2011 Jul-Aug;25(4):797-804. Characterization of chronic pancreatitis in English Cocker Spaniels. Watson PJ, Roulois A, Scase T, Holloway A, Herrtage ME. BACKGROUND: Chronic pancreatitis (CP) is common in dogs. The cause is unknown. In humans, different causes of pancreatitis have histologically distinct appearances. The histopathologic lesions in English Cocker Spaniels (ECS) with CP were noted to be histologically different than those of other breeds with CP. HYPOTHESIS: CP in ECS is distinct from CP in other breeds and is characterized by a duct destruction similar to what is observed in autoimmune CP of humans. ANIMALS: Eight ECS and 9 other breeds with histologically confirmed CP recruited over an 8-year period and 50 postmortem control dogs with CP. METHODS: Clinical, clinicopathological, and ultrasonographic findings were recorded. Histological sections were compared with a normal dog and 59 dogs of other breeds with CP. Immunohistochemistry using anti-CD3, anti-CD79a, and anti-cytokeratin antibodies was used to evaluate distribution and type of lymphocytic inflammation and appearance of pancreatic ducts. RESULTS: Four male and 4 female ECS presented at a mean age of 7.2 years. Clinical signs were similar in ECS and other breeds. The pancreas was enlarged and hypoechoic in 4 ECS and 2 controls. Histopathology was characterized by interlobular and periductular fibrosis and inflammation in ECS compared with intralobular disease in most other breeds. Immunohistochemistry identified prominent anti-CD3(+) lymphocytic infiltrates around venules and ducts and a marked absence of interlobular ducts in ECS compared with mixed T-cell infiltration and ductular hyperplasia in most other breeds with CP. CONCLUSIONS AND CLINICAL IMPORTANCE: CP in ECS is distinct from CP in other breeds and is notably duct destructive.
This is a water cooler
This is a water cooler discussion for sure. Great article Remo!! LP inflammation happens in many organs in the cat and any one organ at any time whether its pancreatitis one day, ibd the next, nephritis, the next, cystitis the next, cholhep the next or any combo of all…. I see it all day long & that’s what comes across the probe.
This is a water cooler
This is a water cooler discussion for sure. Great article Remo!! LP inflammation happens in many organs in the cat and any one organ at any time whether its pancreatitis one day, ibd the next, nephritis, the next, cystitis the next, cholhep the next or any combo of all…. I see it all day long & that’s what comes across the probe.