- One year old intact 74lb male silver Labrador Retriever that has always been PU/PD (but no previous U/A).
- Developed diarrhea after boarding on 4/2/18 – treated with Metronidazole and Pen/Dex injection. Had blood in feces 4/6/18 – diagnosed with coccidia and treated with Albion.
- Started vomiting 4/13/18, urinating all over the house PU/PD worsened… initially thought due to dexamethasone injection. Treated for potential stomach/GI ulcer.
- One year old intact 74lb male silver Labrador Retriever that has always been PU/PD (but no previous U/A).
- Developed diarrhea after boarding on 4/2/18 – treated with Metronidazole and Pen/Dex injection. Had blood in feces 4/6/18 – diagnosed with coccidia and treated with Albion.
- Started vomiting 4/13/18, urinating all over the house PU/PD worsened… initially thought due to dexamethasone injection. Treated for potential stomach/GI ulcer.
- Still vomiting on 4/17/18, blood work indicated significant kidney failure. No know toxin exposure, not sure if chronic or acute renal failure.
- CBC shows HCT=55.2%, PLT=78 K/mcl. Chem prof shows Creat=5.6mg/dL, BUN=110mg/dL, P=7.6mg/dL, Ca=13.8mg/dL, K=4.0mmol/L, Na=148 mmol/L, SDMA=41. U/A showed isosthenuria.
- 2 days of diuresis with IV fluids showed only minimal improvement in the azotemia.
- The abdominal ultrasound showed a very full bladder and kidneys with decreased corticomedullary definition. The left kidney measures 7.33cm in length with a K/Ao of 7.1, and the right kidney measures 8.85cm in length with a K/Ao of 8.6.
- Does the decreased CM definition in this one-year old dog signify chronic degeneration or could this be acute on chronic (renal dysplasia)? The dog is not anemic which seems more acute. I am also wondering if the hypercalcemia is due to crf, toxin, or some other disease (atypical Addisonian, primary hyperparathyroidism, neoplasia unlikely).
Comments
Structurally th ekidneys look
Structurally th ekidneys look ok from a primary standpoint but looks like a chronic insult causing an interstitial nephrosis pattern. Consider chronic lepto here or toxin., needs renal bx. This would not be typical for renal dysplasia but cant absolutely rule it out without bx.
Thx Eric. i had them send
Thx Eric. i had them send the dog to a referral center where he could get more intensive therapy. I will keep the forum postec.
I would not ignore the
I would not ignore the elevated calcium. Have an ionized calcium run.
I would also run a Lepto Titer.