7 year old FS Golden Retriever with 4 weeks hyporexia and weight loss. Hypercalcemia on rDVM blood work and confirmed today with iCa (1.8). Previous abdominal ultrasound reportedly WNL. Normal thoracic rads and rectal exam today. Parathyroid gland measures 2.7 mm, so slightly enlarged and prominent on ultrasound. Sending out PTH today. Do you do ethanol or heat ablation with ultrasound guidance?
7 year old FS Golden Retriever with 4 weeks hyporexia and weight loss. Hypercalcemia on rDVM blood work and confirmed today with iCa (1.8). Previous abdominal ultrasound reportedly WNL. Normal thoracic rads and rectal exam today. Parathyroid gland measures 2.7 mm, so slightly enlarged and prominent on ultrasound. Sending out PTH today. Do you do ethanol or heat ablation with ultrasound guidance?
Comments
Both have been reported to be
Both have been reported to be efefctive and safe:
Guttin T, Knox V, Diroff JS. Outcomes for dogs with primary hyperparathyroidism following treatment with percutaneous ultrasound-guided ethanol ablation of presumed functional parathyroid nodules: 27 cases (2008-2011). J Am Vet Med Assoc. 2015 247:771-7. doi: 10.2460/javma.247.7.771.
OBJECTIVE:
To describe outcomes for dogs with primary hyperparathyroidism following treatment with percutaneous ultrasound-guided ethanol ablation of presumed functional parathyroid nodules.
DESIGN:
Retrospective case series.
ANIMALS:
24 dogs with primary hyperparathyroidism that underwent 27 ultrasound-guided ethanol ablation procedures of presumed functional parathyroid nodules identified by cervical ultrasonography.
PROCEDURES:
Dogs were anesthetized for each procedure. For each nodule, 95% ethanol was injected into the center with ultrasound guidance (volume injected calculated on the basis of ultrasonographic measurements). The interval from treatment to resolution of hypercalcemia, complications, and follow-up clinicopathologic data were recorded.
RESULTS:
5 procedures involved simultaneous treatment of 2 nodules. Three dogs underwent a second treatment because of initial treatment failure or development of another nodule. Hypercalcemia resolved after 23 of 27 (85%) procedures. In those 23 treatments, 22 (96%) had resolution of hypercalcemia within 72 hours after treatment. Hypocalcemia was detected in 6 different dogs at 2 (1 dog), 7 (3 dogs), 14 (1 dog), and 21 (1 dog) days after treatment; 5 of these dogs had mild transient hypocalcemia and 1 developed clinical signs requiring calcium supplementation. Although there were no periprocedural adverse effects, 2 dogs had delayed adverse effects; the overall rate of complications (including delayed adverse events and clinical hypocalcemia) was 11.1%. Long-term follow-up data indicated sustained normocalcemia in 17 of 19 dogs.
CONCLUSIONS AND CLINICAL RELEVANCE:
Results suggested that percutaneous ultrasound-guided ethanol ablation of functional parathyroid nodules may be an effective treatment for primary hyperparathyroidism of dogs, with short duration of anesthesia, minimal complications, and low risk for hypocalcemia.
Pollard RE, Long CD, Nelson RW, Hornof WJ, Feldman EC.
Percutaneous ultrasonographically guided radiofrequency heat ablation for treatment of primary hyperparathyroidism in dogs. J Am Vet Med Assoc. 2001 218:1106-10.
OBJECTIVE:
To evaluate the efficacy and safety of ultrasonographically guided radiofrequency heat ablation of parathyroid masses in dogs with primary hyperparathyroidism.
ANIMALS:
11 dogs.
PROCEDURE:
In all dogs, either 1 or 2 parathyroid masses were evident ultrasonographically. Dogs were anesthetized, and a 20-gauge over-the-needle catheter was directed into the parathyroid mass via ultrasonographic guidance. Radiofrequency heat was applied to the stylet of the catheter until there was sonographically apparent change to the entire parenchyma of the mass. Serum total and ionized calcium and parathyroid hormone concentrations were monitored daily for 5 days after the ablation procedure and again at 1, 2, and 3-month intervals, if possible. Dogs were monitored for adverse effects.
RESULTS:
One treatment was required in 6 dogs, 2 treatments were required in 2 dogs, and treatment was unsuccessful in 3 dogs. Serum total and ionized calcium concentrations were within reference ranges within 2 days of the last procedure in all 8 successfully treated dogs. Serum parathyroid hormone concentration was decreased 24 hours after treatment in all 8 dogs. Hypocalcemia developed in 5 of the 8 successfully treated dogs, all of which required treatment. One dog had a transient voice change. Other adverse effects were not reported.
CONCLUSIONS AND CLINICAL RELEVANCE:
Ultrasonographically guided radiofrequency heat ablation of parathyroid masses is a safe and effective alternative to surgery in dogs with primary hyperparathyroidism.
That’s a small one but if the
That’s a small one but if the PTH is high normal to elevated then i would cut it. But need to describe exactly for the surgeon as it doesnt look like it is pushing on the capsule much to see overtly in sx.
I never did thanol ablation and all i have talked to have gone away from it caused more trouble than it was worth. I just sent to sx its an easy sx for those that know how to do it.
Agree with Eric – surgery is
Agree with Eric – surgery is quicker and simpler.