US and CYT- Likely splenic and liver carcinoma with supporting FNA/cytology in a 9 year old FS dog

Case Study

US and CYT- Likely splenic and liver carcinoma with supporting FNA/cytology in a 9 year old FS dog

This 9 year old FS dog presented with a one month history of weight loss, ADR. Splenic sample submitted for telecytology too.

Physical Exam: Thin, palpable abdominal left sided mass

CBC/Chem: ALT 170

 

This 9 year old FS dog presented with a one month history of weight loss, ADR. Splenic sample submitted for telecytology too.

Physical Exam: Thin, palpable abdominal left sided mass

CBC/Chem: ALT 170

 

Image Interpretation

Moderate splenic enlargement with multiple complex hypoechoic expansile mass
lesions up to 4 cm diameter is noted. The splenic capsule reveals interruptions with
protrusion of anechoic masses (potential fresh hematoma). There is moderate hepatomegaly. Multifocal expansile hypoechoic nodules are seen
throughout all liver lobes displacing the regular echotexture and expanding the capsule. A moderate amount of peritoneal effusion is noted. The mesentery is irregular
throughout with multifocal complex anechoic nodules.

DX

The ultrasonographic findings suggest a ruptured splenic mass with hemorrhagic peritoneal effusion and/or mesenteric carcinomatosis There is capsular disruption and perilesional hematomas as well as multifocal expansile liver nodules – peritoneal tumor seeding and metastatic spread to the liver is likely.

Outcome

The potential of a malignancy such as hemangiosarcoma is high in this case as the
presence of rupture and hemorrhage is a recognized malignancy criteria. Hemorrhage
from a liver nodule may contribute to the effusion as well.
The potential of the splenic and liver changes to be benign is very low.
Final diagnosis and full staging would require FNA of the spleen with liver and
mesenteric sampling as well as a 3 view radiographic study of the chest and
sonographic evaluation of the heart base for possible masses/pericardial effusion.
Exploratory surgery with splenectomy plus chemotherapy may be discussed as a
palliative measure after stabilizing the patient since mean survival times even with
metastatic spread may be up to 90 days.
The overall prognosis appears to be poor.

Sampling

FNA/telecyotology of spleen and liver. Spleen: inflammation, but inadequate number of cells. Liver: hemorrhagic collection of cells with good numbers of hepatocytes supporting probable hepatocellular adenoma or carcinoma. Recommend follow-up liver biopsy.

Patient Information

Patient Name : Dakota Thompson/Bayshore
Gender : Female, Spayed
Species : Canine
Type of Imaging : Ultrasound
Status : Complete
Liz Wuz Here : Yes

Clinical Signs

  • Weight loss

Exam Finding

  • Masses
  • Underweight

Images

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Blood Chemistry

  • ALT (SGPT), High

Clinical Signs

  • Weight loss
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