Antech’s new Canine Chronic enteropathy IBD assay

Sonopath Forum

Sonopath Forum

Antech’s new Canine Chronic enteropathy IBD assay

Just wondering what the sonopath specialist’s thoughts are on Antech’s new biomarker assay for chronic enteropathy and IBD. I am especially interested since a lot of chronic vomiting and diarrhea dogs may have minimal ultrasound findings but the owners end up not pursuing GI biopsies from what I believe to be issues of cost, fear of anesthesia/sx, or lack of strong recommendations from the primary vet. Are any of you using these tests and have you found them to be helpful?

Comments

EL
April 16, 2021 at 12:12 pm -

Lots of discussion on it on

Lots of discussion on it on abvp list serve and my int med crew chimed in but its essentially an adjunct test. I of course am nore concerned what the wall layers and mucosal changes are sonographically on hi res. What is the submucosal layer doing? Is it disrupted suggesting neoplastic criteria? Are there mucosal striations or fogging? What do the LNs look like? Most of what I have seen form those that don’t rely on ultrasound like we do add it as part of the GI panel.

B12, folate, cPLI/cTLI, GI pathogen PCR and the CE/IBD assay.

Heres the link to the JVIM article on it

https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.15761

 

 

EL
April 16, 2021 at 12:40 pm -

Here’s an except from a

Here’s an except from a specialist involved with the test:

 

The CE/IBD test can be useful is used appropriately, but has limitations like all tests. It is NOT a screening test, so this is not for animals that came in for any acute condition.  This is only for animal with chronic GI symptoms. We know that CE can be subdivided into multiple categories – food-responive, antibiotic-responsive, immunosuppressive-responsive, etc. This test can help give you more information to try to distinguish between these.  It can help not only formulate your initial treatment plan, but (I think even better) be used repeatedly at follow-ups to give you an objective measurement of how your treatments are working. If you get extremely high levels on ACNA, you should be looking more closely for neoplasia.
 
There are questions regarding the anti-gliadin aspect as to whether this truly represents a gliadin allergy or whether these numbers are just high as a result of increased mucosal permeability.  It’s a very chicken or the egg situation. From personal experience, I think there are more dogs out there with true gliadin sensitivity than we realized. My own dog was part of the study. She had been on metoclopramide and omeprazole for 6 years and I was able to take her off of all meds by excluding gliadin from her diet. 
 
The cat study is currently underway.  This test is a bit different from the dog with different markers. The line between IBD and lymphoma is much more blurred – you can biopsy multiple places in the intestine and gets 2 saying IBD and 1 saying lymphoma. Currently the test has a predicted sensitivity of 95% and specificity of 90% for differentiating IBD from neoplasia (note I will not specifically say GI lymphoma – if a cat has IBD and a bladder TCC I don’t know what the test would say, that’s a hard population to find and sample). 
 
 
 
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