Interstitial cystitis. Potential concurrent urinary tract infection. Full thickness bladder wall biopsy is recommended.
Interstitial nephrosis with pyelectasia. Renal biopsy can also be considered given convenience of the procedure given that the bladder wall biopsy is ideal in this case for long term management. Urine culture and sensitivity, pain measurement, behavioral issues and glucosamine support can all be considered in this patient. I do not recommend cortisone usage unless histopathology of the bladder wall would suggest a lymphoplasmacytic infiltrate. Bladder lymphoma is also a mild potential.