Splenic plasmacytoma diagnosed by FNA in a 10 year old MN DLH cat

Case Study

Splenic plasmacytoma diagnosed by FNA in a 10 year old MN DLH cat

A 10-year-old MN DLH presented for vomiting, depression, and weakness. Clinical exam findings were uneventful. The complete blood count revealed anemia (PCV 16% – 3+ anisocytosis, 2+ polychromasia, 2+ rouleaux present), neutropenia 1659 (n 2500-8500) and lymphocytopenia 273 (n 1200-8000). Blood chemistry revealed slightly elevated total bilirubin.

A 10-year-old MN DLH presented for vomiting, depression, and weakness. Clinical exam findings were uneventful. The complete blood count revealed anemia (PCV 16% – 3+ anisocytosis, 2+ polychromasia, 2+ rouleaux present), neutropenia 1659 (n 2500-8500) and lymphocytopenia 273 (n 1200-8000). Blood chemistry revealed slightly elevated total bilirubin.

Sonographic Differential Diagnosis

Early splenic infiltration with round cell neoplasia (lymphoma, mast cell disease, multiple myeloma) is strongly suspected, especially if clinical signs are consistent with these disease processes. Reactive hyperplasia or equivalent benign pathology is a lesser possibility

Image Interpretation

Images show mild, uniform splenic enlargement (approximately 1.3 cm in width). The parenchyma demonstrates subtle mottled to micronodular changes and slight heterogenicity consistent with a “honeycomb” appearance.

DX

Extramedullary plasmacytoma.

Outcome

No further outcome provided.

Comments

Bone marrow biopsy would have been necessary to explain the anemia and neutropenia but was declined by the owner.

Clinical Differential Diagnosis

Regenerative anemia – IMHA or blood loss. However a reticulocyte count would be necessary to confirm a regenerative process. Given the presence of concurrent neutropenia and the absence of overt infection, lack of production or increased destruction by the bone marrow is likely and could also reflect the source of the anemia. Therefore other differentials include primary bone marrow disease (especially if the anemia is actually non-regenerative) such as aplastic anemia, myelofibrosis, myelodysplasia, myeloproliferative disease/ hemopoetic neoplasia, mast cell disease, lymphoma, FeLV infection, as well as other infectious diseases such as various vector borne diseases (Mycoplasma, ehrlichiosis etc).

Sampling

US-guided fine needle aspiration of the spleen revealed extramedullary plasmacytoma.

Patient Information

Patient Name : Checkers D
Gender : Male, Neutered
Species : Feline
Type of Imaging : Ultrasound
Status : Complete
Liz Wuz Here : Yes
Code : 08_00037

Clinical Signs

  • "Not Doing Right"
  • Depression
  • Vomiting
  • Weakness

Images

checkers

Blood Chemistry

  • Total Bilirubin, High

CBC

  • Anisocytosis
  • Hematocrit, Low
  • Lymphocytes, Low
  • Neutrophils, Low
  • Polychromasia

Clinical Signs

  • "Not Doing Right"
  • Depression
  • Vomiting
  • Weakness
Skip to content