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Decreased appetite. Current meds: Metronidazole, Denamarin, Mirtazapine. ALT 393, T. bili 5.7, Mag 2.7, Chol 307, Amyl 1891, PSL 50, Lymphs 9, Mono 8, Neuts 11,680, Mono 1280,Eos. 1600, USG 1.048.
Decreased appetite. Current meds: Metronidazole, Denamarin, Mirtazapine. ALT 393, T. bili 5.7, Mag 2.7, Chol 307, Amyl 1891, PSL 50, Lymphs 9, Mono 8, Neuts 11,680, Mono 1280,Eos. 1600, USG 1.048.
Concern for post hepatic obstruction; possibility of a concurrent hepatic lymphoma as the cause due to the clinical profile. The common bile duct appears to taper into the duodenal papilla adequately. Recommend screening via ultrasound-guided FNA of the liver and spleen to ensure that no obvious lymphoma is present followed by surgical intervention with cholecystectomy and common bile duct lavage. Ultrasound guided FNAs of both the spleen and liver were performed without complication. Cytology results: Liver – Chronic pyogranulomatous hepatitis with hepatocellular vacuolization and probable early feline fatty liver syndrome. Spleen – Chronic suppurative splenitis with extramedullary hematopoiesis.Two separate issues are likely at play in this patient with the possibility of hepatic lymphoma. At last recheck, the patient was found to be doing well on current treatments of Denamarin, Metronidazole, and Ursodiol.
Additional cytology notes: “The changes in the liver support chronic inflammation and evidence of secondary hepatocellular change. This could be due to biliary obstruction or possibly due to pancreatitis ascending up the biliary tree with inflammation. There is no suggestion of malignancy nor do we find changes supporting sepsis. The changes are more characteristic of chronic inflammation which is likely secondary to the biliary problem or pancreatitis. The changes in the spleen are likely secondary to the problems in the liver. This could be due to inflammation in the biliary tree, pancreatitis or other changes. There is no suggestion of neoplasia or sepsis in the spleen. Further treatment for the gallbladder obstruction and possible pancreatitis was encouraged in this case.” – Larry McGill, DVM, PH.D., DACVP.
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Ultrasound guided FNAs of both the spleen and liver were performed without complication.
Spleen: The spleen was mildly enlarged with uniform, but subtly micronodular parenchyma, and undulating capsular contour. This is consistent with reactive spleen owing to immune stimulus or early infiltrative disease such as mast cell disease or lymphoma.
Liver: The hepatic parenchyma was uniformly swollen. Lobar biliary duct dilation was noted owing to post hepatic obstruction. The gallbladder revealed a 1.13 cm calculus with echogenic debris. The gallbladder wall was mildly thickened and echogenic. The common bile duct was followed to the duodenal papilla. The common bile duct appeared to taper normally, yet the common bile duct was excessively dilated up to 0.5 cm. The hepatic lymph nodes are slightly enlarged and measured 0.6 cm.
