Can someone help me understand the difference between these two terms, and also the difference in ultrasound appearance?
Thanks,
Liz
Can someone help me understand the difference between these two terms, and also the difference in ultrasound appearance?
Thanks,
Liz
Comments
Nephritis implies an
Nephritis implies an inflammatory reaction – infection, immune-mediated; whereas nephrosis implies degeneration associated with hypoxia and possibly toxins. The two terms are often used interchangeably. Not sure if there is an ultrasonographic difference between the two.
Nephritis implies an
Nephritis implies an inflammatory reaction – infection, immune-mediated; whereas nephrosis implies degeneration associated with hypoxia and possibly toxins. The two terms are often used interchangeably. Not sure if there is an ultrasonographic difference between the two.
Intertstitial nephrosis is
Intertstitial nephrosis is the most common form of degenerative renal disease in cats when you get histopath. Renal function is a different concept than nephrosis. Chronicity of nephrosis can exist but the renal reserve allows for adequate function til 60-70% of the parenchyma is compromised or inciting factors such as concurrent uti, thrombosis, hypertension, hypert4, cardiac disease, neoplasia, pancreatitits or other prerenal/toxic/vasoactive amine factors push the kidneys over the edge. I see a lot of cats with subjectively 40-50% compromised kidneys structurally that have concurrent pancreatitis sonographically (+ murphy sign, swelling, hypoechoic, dilated duct…) and present with renal failure (BUN Creat low usg) but respond dramatically well when treated with a renal/pancreatitis “protocol.” I would love to have histopath on both organs in these cases but for now its just a repetitive observation. Hence, I look for things I can treat when the kidneys don’t look “end stage” but may have an intertsitial nephrosis pattern to them.
Attached is a typical interstitial nephrosis cat kidney confirmed on usg bx. There are many variations of this type of presentation but this one is prototypical.
Intertstitial nephrosis is
Intertstitial nephrosis is the most common form of degenerative renal disease in cats when you get histopath. Renal function is a different concept than nephrosis. Chronicity of nephrosis can exist but the renal reserve allows for adequate function til 60-70% of the parenchyma is compromised or inciting factors such as concurrent uti, thrombosis, hypertension, hypert4, cardiac disease, neoplasia, pancreatitits or other prerenal/toxic/vasoactive amine factors push the kidneys over the edge. I see a lot of cats with subjectively 40-50% compromised kidneys structurally that have concurrent pancreatitis sonographically (+ murphy sign, swelling, hypoechoic, dilated duct…) and present with renal failure (BUN Creat low usg) but respond dramatically well when treated with a renal/pancreatitis “protocol.” I would love to have histopath on both organs in these cases but for now its just a repetitive observation. Hence, I look for things I can treat when the kidneys don’t look “end stage” but may have an intertsitial nephrosis pattern to them.
Attached is a typical interstitial nephrosis cat kidney confirmed on usg bx. There are many variations of this type of presentation but this one is prototypical.