A 12-year-old FS mixed breed dog with an extensive history of urinary calculi and three cystotomies to date was presented for a swollen right hind paw. On physical examination, the skin of the foot was inflamed with alopecia and crusting; there was generalized peripheral lymphadenomegaly, and a firm mass was palpated in the area of the bladder. The only change on CBC was thrombocytosis. On blood chemistry hyperglobulinemia, elevated ALP activity, hypercalcemia, and hypertriglyceridemia was present. Total T4 was within normal limits.

A 12-year-old FS mixed breed dog with an extensive history of urinary calculi and three cystotomies to date was presented for a swollen right hind paw. On physical examination, the skin of the foot was inflamed with alopecia and crusting; there was generalized peripheral lymphadenomegaly, and a firm mass was palpated in the area of the bladder. The only change on CBC was thrombocytosis. On blood chemistry hyperglobulinemia, elevated ALP activity, hypercalcemia, and hypertriglyceridemia was present. Total T4 was within normal limits. Survey radiographs of the abdomen showed urinary calculi, hepatomegaly, and splenomegaly. The patient was treated with antibiotics and Benadryl at home. On follow-up visit three days later, owner reported that the patient had been showing polyuria/polydipsia for a few months. Hypercalcemia of malignancy profile revealed an elevated intact parathyroid hormone and elevated ionized calcium level. Thoracic metastasis was not evident on 3-view thoracic radiographs.