Prostatic carcinoma diagnosed by FNA in a 11 year old MN Cocker Spaniel dog

Case Study

Case Study

Prostatic carcinoma diagnosed by FNA in a 11 year old MN Cocker Spaniel dog

A 11 year old NM Cocker Spaniel with a history of cystadenocarcinoma and persistently increased microalbuminuria was presented with a mass on the right toe. FNA cytology showed atypical epithelial cells and, on biopsy, an adenocarcinoma was diagnosed. Prostatomegaly was present on physical examination. Abnormalities on blood chemistry were hypoalbuminemia, hyperglobulinemia, low albumin/globulin ratio, elevated BUN/creatinine ratio, elevated amylase, and elevated BUN.

A 11 year old NM Cocker Spaniel with a history of cystadenocarcinoma and persistently increased microalbuminuria was presented with a mass on the right toe. FNA cytology showed atypical epithelial cells and, on biopsy, an adenocarcinoma was diagnosed. Prostatomegaly was present on physical examination. Abnormalities on blood chemistry were hypoalbuminemia, hyperglobulinemia, low albumin/globulin ratio, elevated BUN/creatinine ratio, elevated amylase, and elevated BUN.

DX

Prostatic carcinoma

Sonographic Differential Diagnosis

Prostatic mass, cystic and mineralizing. Prostatic carcinoma likely. Prostatitis and abscessation possible but less likely.

Image Interpretation

The prostate is excessively rounded, cystic with dramatically hypoechoic parenchyma and focal areas of mineralization. This presence in a neutered male is highly suggestive for prostatic carcinoma with potential secondary abscessation.

Outcome

The patient was started on piroxicam and referred for further evaluation. Survey thoracic radiographs showed pulmonary metastasis, and the patient was subsequently euthanized.

Comments

 
 

We have found that often the clinical signs in these patients are caused by cystic expansion within the prostate and will respond temporarily with US-guided cyst drainage and antibiotic injection if the fluid appears inflammatory. This procedure together with NSAID therapy and/or chemotherapy or potential urethral stent placement may allow for considerable maintenance of quality of life. The drainage may be repeated as needed. Studies are ongoing at SonoPath.com. Theoretically, tracking opf prostatic carcinoma into the dermal tissue could occur but has not been our experience after hundreds of samples taken from prostates in this manner. Traumatic catheterization is a non-invasive option, but not as precise in our experience. When expansive cysts must be drained, us-guided sampling of the prostate provides the best diagnostic and therapeutic value in these cases.

 

Clinical Differential Diagnosis

Metastatic neoplasia. Prostatic enlargement – neoplasia, abscessation, hyperplasia secondary to exogenous hormonal therapy. Chronic liver disease. Chronic renal disease.

Sampling

FNA cytology of the prostate was suggestive of carcinoma.

Video

Patient Information

Patient Name : Sam Pehush
Gender : Male, Neutered
Species : Canine
Type of Imaging : Ultrasound
Book : yes
Status : Complete
Liz Wuz Here : Yes
Code : 09_00006

Clinical Signs

  • Cutaneous mass

History

  • Albuminuria
  • Neoplasia

Exam Finding

  • Prostatic enlargement

Images

PehushProstMeas

Blood Chemistry

  • Albumin, Low
  • Albumin/Globulin Ratio, Low
  • Amylase, High
  • BUN high
  • BUN/Creatinine Ratio, High
  • Globulin, High

Clinical Signs

  • Cutaneous mass
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