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Likely transitional cell carcinoma in a 13 year old MN mixed breed dog with ventral and urethral bladder lesions

Case Study

Likely transitional cell carcinoma in a 13 year old MN mixed breed dog with ventral and urethral bladder lesions

A 13-year-old MN mixed breed dog was presented for evaluation of a 2-3 month history of dysuria and incontinence.  Urine culture was positive for E. coli and he had been treated with 2-week course of Simplicef.  On urinalysis, atypical epithelial cells were seen.

A 13-year-old MN mixed breed dog was presented for evaluation of a 2-3 month history of dysuria and incontinence.  Urine culture was positive for E. coli and he had been treated with 2-week course of Simplicef.  On urinalysis, atypical epithelial cells were seen.

DX

Carcinoma vs polyploid hyperplasia of the bladder

Sonographic Differential Diagnosis

carcinoma

Image Interpretation

The urinary bladder in this patient presented two separate lesions. One appeared to be a mural lesion in the ventral aspect of the bladder and measured approximately 1.0 cm with a separate polypoid mass at the ventral caudal aspect of the bladder. Focal areas of mineralization were noted. This is suggestive for carcinoma, possible polypoid hyperplasia. The general ventral wall of the bladder appeared variably thickened with loss of mural detail. The ventral mural mass would be the region of cystocentesis. Therefore, focal hematoma is possible; however, this appears to have a tissue thickening. The mineralizing mass at the caudal aspect of the bladder measured 1.5 cm. The mineralizing mass enters into the cystourethral junction and urethra. Given the penetration into the pelvic urethra this does not appear resectable. Penetration was at least 1.0-2.0 cm distal from the cystourethral junction. The deep urethra from the point of approximately 2.0 cm caudal from the cystourethral junction appeared to be free of evident pathology, yet micrometastasis is entirely possible. Concurrent sand was also present, yet it is not the primary issue in this case. Portions of the mass appeared to enter into the residual prostate.

The right kidney revealed an anechoic cyst that measured 0.48 cm along with mild degenerative changes and mildly thickened cortices. The right kidney measured 7.35 cm. 

Outcome

Guarded prognosis. Traumatic catheterization with ultrasound guidance with tissue analysis is recommended to confirm suspicion of carcinoma. Urethral stent placement could be considered in this patient as a palliative measure via interventional radiologist

Clinical Differential Diagnosis

Bladder – neoplasia, urolith, bacterial cystitis, polyploid cystitis
Prostate – neoplasia, abscess
Urethra – neoplasia, lith

Patient Information

Patient Name : Tebo Reney
Gender : Male, Neutered
Species : Canine
Type of Imaging : Ultrasound
Status : Complete
Liz Wuz Here : Yes
Code : 06_00357

Clinical Signs

  • Dysuria
  • Incontinence

Images

464849

Clinical Signs

  • Dysuria
  • Incontinence

Urinalysi

  • Epithelial Cells Present