A 6-year-old FS DSH cat was presented for behavioral changes, polydipsia, and decreased appetite. Abnormalities on physical examination were marked dehydration, icteric mucous membranes, a pendulous and difficult to palpate abdomen, unkempt haircoat, flaking skin with matted hair, and severe dental disease. CBC showed low HCT, lymphopenia, and eosinophilia. On blood chemistry elevated ALT and elevated ALP activity, marked hyperbilirubinemia, mild hypercholesterolemia, and decreased CK were evident. Negative FELV, negative FIV, negative FIP, and toxoplasma assays were all negative.

A 6-year-old FS DSH cat was presented for behavioral changes, polydipsia, and decreased appetite. Abnormalities on physical examination were marked dehydration, icteric mucous membranes, a pendulous and difficult to palpate abdomen, unkempt haircoat, flaking skin with matted hair, and severe dental disease. CBC showed low HCT, lymphopenia, and eosinophilia. On blood chemistry elevated ALT and elevated ALP activity, marked hyperbilirubinemia, mild hypercholesterolemia, and decreased CK were evident. Negative FELV, negative FIV, negative FIP, and toxoplasma assays were all negative. T-4 was within normal range. The patient was treated with I.V. fluids, antibiotics, Ursodial, and supportive care. 24 hours later she began eating small meals, but 3 days later started to vomit uncontrollably. Follow up liver profile showed an improvement in the ALP activity, normalization of ALT activity, and ongoing hyperbilirubinemia. Anti-emetics were added to the therapy and the antibiotics temporarily discontinued. Three days later blood chemistry showed ongoing improvement in ALP activity, slightly decreased BUN, hypercholesterolemia, hyperglycemia, and hyperbilirubinemia. Blood gases showed an alkalosis with elevated HCO3 and decreased tCO2, hypokalemia, and decreased chloride.