The small intestines are diffusely, moderately to markedly thick walled and abnormally layered, represented by a severely thickened muscularis layer (arrow). Subtle loss of wall layering is also noted. The long axis view of the ileocecal region further demonstrates muscularis thickening and loss of mural detail (arrow.) Mild to moderate bowel wall thickening persisted after 2 months of therapy. On recheck ultrasound, the muscularis layer is persistently prominent (wide arrow); however, discrete wall layering is now visualized (thin arrow).