A 9-year-old NM Cocker Spaniel with a history of lethargy, weight loss, and decreased appetite was presented for evaluation of progressive icterus. On physical examination mildly tense abdomen and icterus were present. Urinalysis showed SG of 1.022, hematuria, proteinuria, and bilirubinuria with E. coli being cultured. Abnormalities on CBC and serum biochemistry were mild lymphopenia, mild neutrophilia, mild hyponatremia and hypokalemia, severely elevated ALT (944), AST (598) and ALP (5088) activity, bilirubin (20.1), CK (1516), and cPL (401).