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Protein losing nephropathy, glomerulonephritis, and uremic gastritis in a 3-year-old Intact male Labrador Retriever: Our Case Of The Month December 2014

Case Of the Month

Case Of the Month

Protein losing nephropathy, glomerulonephritis, and uremic gastritis in a 3-year-old Intact male Labrador Retriever: Our Case Of The Month December 2014

A 3-year-old male Labrador Retriever dog was presented for anorexia and weight loss. CBC was within normal limits, however blood chemistry showed hyperproteinemia, hypoalbuminemia, low albumin/globulin ratio, marked azotemia, hyperphosphatemia, mild hypocalcemia, hyperkalemia, and hyperamylasemia. T4 was within normal range. The urine had a cloudy appearance; 3+ proteinuria and 3+ hematuria were present on urinalysis.

A 3-year-old male Labrador Retriever dog was presented for anorexia and weight loss. CBC was within normal limits, however blood chemistry showed hyperproteinemia, hypoalbuminemia, low albumin/globulin ratio, marked azotemia, hyperphosphatemia, mild hypocalcemia, hyperkalemia, and hyperamylasemia. T4 was within normal range. The urine had a cloudy appearance; 3+ proteinuria and 3+ hematuria were present on urinalysis.

DX

Protein-losing nephropathy, glomerulonephritis, uremic gastritis.

Outcome

The patient was euthanized due to financial concerns and poor prognosis.

Clinical Differential Diagnosis

Renal disease – acute, chronic, congenital, pyelonephritis, neoplasia. Nephrotic syndrome. Primary glomerulonephritis with secondary renal failure.

Sonographic Differential Diagnosis

Glomerulonephritis – protein losing nephropathy. Suspect Lyme nephritis, or similar immune complex disease. Uremic gastritis.

Image Interpretation

The kidneys present thickened and uniformly echogenic cortices that are hypervascular on power Doppler evaluation. Slight pyelectasia is present due either to fluid therapy (< 0.3 cm) or due to infection (pyelonephritis). The gastric wall is edematous and uniformly thickened consistent with gastritis.

Video

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Patient Information

Gender : Male, Intact
Species : Canine

Clinical Signs

  • Anorexia
  • Weight loss

Exam Finding

  • Weight loss

Images

leftkidneykidneypowerleftkidneystomach

Blood Chemistry

  • Albumin, Low
  • Albumin/Globulin Ratio, Low
  • Amylase, High
  • Azotemia
  • BUN high
  • Calcium, Low
  • Creatinine, High
  • Phosphorus, High
  • Potassium, High

Clinical Signs

  • Anorexia
  • Weight loss

Urinalysi

  • Appearance Turbid
  • Blood Present
  • Protein Present