PDH vs. ADH in an 8-year-old FS Pit Bull Terrier: Our Case Of the Month June 2016

Case Of the Month

PDH vs. ADH in an 8-year-old FS Pit Bull Terrier: Our Case Of the Month June 2016

An 8-year-old, F/S, 77 lb, Pitbull terrier was presented at RDVM for decreased activity level and behavioral changes. Blood work was performed and showed an increase in ALKP. The patient also had a dental cleaning recently where they extracted multiple teeth and put her on oral Tramadol. Owner says that she was “normal” on March 20th but has slowly been declining. Repeat blood work showed an increase in ALKP. Unable to perform physical exam due to hyper response. Owner reported the patient had become very head shy and aggressive with other dogs and had drastically changed in personality.

An 8-year-old, F/S, 77 lb, Pitbull terrier was presented at RDVM for decreased activity level and behavioral changes. Blood work was performed and showed an increase in ALKP. The patient also had a dental cleaning recently where they extracted multiple teeth and put her on oral Tramadol. Owner says that she was “normal” on March 20th but has slowly been declining. Repeat blood work showed an increase in ALKP. Unable to perform physical exam due to hyper response. Owner reported the patient had become very head shy and aggressive with other dogs and had drastically changed in personality. RDVM recommended a brain CT scan and it was decided to include the liver due to increased ALKP.

Outcome

Recommendations were for laboratory workup for possible Cushing’s and ultrasound guided fine needle aspiration of the liver for further definition. Medical treatment may be considered versus or in combination with radiation therapy.

Image Interpretation

Head: An extraaxial mass lesion of 1.5 cm diameter is seen within the third ventricle of the brain. The lesion is associated with the chroid plexus, irregular in shape and reveals marked non-uniform contrast enhancement. The lateral ventricles are dilated. The mesencephalic aqueduct and fourth ventricle are normal in size. A second strongly enhancing extraaxial mass lesion is seen in the midline dorsal to the sella turcica. The lesion measures 6 x 6 x 10 mm and exerts a mass effect on the surrounding brain parenchyma including the optic chiasm. Abdomen: The liver reveals moderate generalized enlargement with lobar swelling and mild parenchymal heterogeneity. The vascular architecture of the liver is within normal limits. Both adrenal glands reveal mild symmetric enlargement. Overall assessment: The computed tomography reveals two extraparenchymal intracranial mass lesions – one within the third ventricle and one within the pituitary fossa. The most likely diagnoses are a choroid plexus tumor for the intraventricular and a pituitary macroadenoma for the second mass. Ependymoma, meningioma, cranipharyngioma and round cell neoplasia are possible but less likely differential diagnoses. A moderate secondary hydrocephalus internus occlusivus of the lateral ventricles is noted. Increased intracranial pressure is assumed. The findings of the liver are suggestive for diffuse parenchymal disease such as inflammatory, vacuolar or neoplastic infiltration. Together with the mild symmetric adrenal hyperplasia and the intracranial changes a pituitary dependent hyperadrenocorticism with steroid induced hepatitis is the most likely diagnosis.

Patient Information

Patient Name : K Edmonds Neel Vet case
Gender : Female, Spayed
Species : Canine
Status : Complete
Code : 16_00006

Clinical Signs

  • "Not Doing Right"
  • Aggression

Images

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Blood Chemistry

  • Alkaline Phosphatase (SAP), High

Clinical Signs

  • "Not Doing Right"
  • Aggression
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