Patient was presented for ataxia, icterus, lethargy, and vomiting.
Patient was presented for ataxia, icterus, lethargy, and vomiting. History of atypical vaccine reaction after first DHLPP–ADR, enlarged peripheral LN. The patient has not been 100% since. Blood chemistry and CBC revealed BUN 3, TP 4.3, Alb 1.9, ALT 457, ALKP 869, GGT 20, Tbili 5.1, chol 84, amylase 216 and HCT 31%.
Splenoazygos shunt is suspected. This is an extreme shunt fraction. An attempt at medical stabilization could be considered with potential surgical intervention. However, the size of the shunt is considerable and it is debatable on whether the liver would be able to handle the flow adequately without forming portal hypertension.Medical stabilization and CT for surgical planning and referral to Dr. Weisse at Animal Medical Center would be the preference for this case. Concurrent renal dysplasia is suspected; however, given the structural changes, the swelling of the kidneys can be justified by altered ammonia metabolism. Plasma transfusion as well as plasma expanders are likely in this patient’s best interest. After a prognosis of extremely guarded to poor, the patient was humanely euthanized.
Hepatic Support for Bile Acid Elevation +/–Hepatic Encephalopathy: Royal Canin Hepatic Support diet or Hills L/D, Metronidazole (7.5 mg/kg PO bid) over the next 14 days, Lactulose (Oral: 3.1–3.7 g/5 ml lactulose in a syrup base) long term to target 2–3 soft stools/day, with a high–quality protein supplement of minor amount of yogurt or cheddar cheese. Monitor bile acids, with attention paid to dropping albumin, BUN or cholesterol. SAMe and nutraceuticals as needed. Ursodiol (10–15 mg/kg p.o. q24h) can be considered as hepatoprotectant and to enhance bile flow. Zincserum level keep between 200—500 ug/dl. If deficient then Tx zinc acetate 1–3 mg/kg/day. Gastrointestinal protectants are recommended if the patient is anorexic.
Liver: The liver was subnormal in size with increased portal markings. The portal vein was subnormal in size at its termination and measured 0.3 cm. The vena cava was subnormal in size likely owing to volume contraction and extrahepatic portosystemic shunting. The vena cava measured 0.3 cm. A large extrahepatic portosystemic shunt was noted in the vicinity of the right kidney. This appears to be deriving from the portal system, bypassing the vena cava and entering in through the aortic hiatus. This is likely a splenoazygos shunt. Minimal volume was present entering into the portal vein. The vena cava was subnormal in volume. The shunt appeared to be present near the esophageal hiatus. This is typical for azygos shunting. Double aorta appeared to be present as well. Kidneys: The kidneys were both swollen with some loss of corticomedullary definition. The left kidney presented an irregular renal pelvis. Primary dysplasia may be an issue. Blood flow was adequate to hypervascular. The left kidney measured 6.81 cm. The right kidney measured 6.96 cm.
