Bilateral adrenal masses in a 16 year old FS Cockapoo

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Bilateral adrenal masses in a 16 year old FS Cockapoo

  • This is a 16 year old, FS, Cockapoo with elevated cortisol levels on a LDDT, isosthenuria, urine protein to creatinine ratio>3.0, ALT=165.The dog is currently on amlodipine and enalapril for systemic hypertension.
  • Abdominal ultrasound shows bilateral adrenal gland masses, splenic hilar thrombus, multiple, bilateral, renal cortical cysts, and heterogeneous hepatic parenchyma.
  • The left adrenal gland mass is mineralzied.  The right adrenal gland mass is >4.0cm in diameter.  It is complex with multiple nodules and possible cysts.  
    • This is a 16 year old, FS, Cockapoo with elevated cortisol levels on a LDDT, isosthenuria, urine protein to creatinine ratio>3.0, ALT=165.The dog is currently on amlodipine and enalapril for systemic hypertension.
    • Abdominal ultrasound shows bilateral adrenal gland masses, splenic hilar thrombus, multiple, bilateral, renal cortical cysts, and heterogeneous hepatic parenchyma.
    • The left adrenal gland mass is mineralzied.  The right adrenal gland mass is >4.0cm in diameter.  It is complex with multiple nodules and possible cysts.  
    • The left adrenal gland does not show vascular invasion.  Patient movement precluded full color flow Doppler evaluation of the right adrenal gland for local vascular invasion.
    • Would it be safe to say that this is NOT pituitary based hyperadrenocorticism or is an FNA required?  I have not seen such an atypical right adrenal gland with PDH.
    • What treatment options are available if both adrenal glands have masses?  Surgical debulking or just trilostane or mitotane with Plavix and blood pressure control?

     

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